Quest International Journal of Medical and Health Sciences

Artificial Intelligence and Cognitive Decline: A Grave Concern

2026-01-28T15:03:55+00:00

No abstract available.

MicroRNAs: Diagnostic and Therapeutic Implications in Diabetes Mellitus

2026-01-28T15:03:21+00:00

ABSTRACT

Introduction:

MicroRNAs are a class of RNA (ribonucleic acid) that bind to mRNAs, leading to a decreased or complete cessation of protein synthesis. Dysregulation in microRNAs (miRNAs) has been associated with the development of diabetes mellitus. MiRNA-133a is responsible for the anti-apoptotic mechanism within the heart, and is thus cardioprotective via means of repression of cardiac fibrosis. In the kidney, the overexpression of miR-192 leads to increased collagen formation and deposition in the extracellular matrix (ECM). miR-34a is also overexpressed, leading to the suppression of anti-apoptotic proteins and an increase in reactive oxygen species (ROS), thereby promoting podocyte apoptosis. In terms of diagnosis, serum miR-126 has demonstrated high specificity and sensitivity in distinguishing progressive from non-progressive diabetic retinopathy.

Conclusion:

Understanding the action of modulating specific miRNAs can be beneficial for treating or reducing inflammation or fibrosis, thus preventing complications and aggravation in diabetic patients.

Knowledge, Attitude, and Practice of Basic Life Support (BLS) among the Students of Quest International University: A Cross-Sectional Study from Ipoh, Perak, Malaysia

2026-01-28T15:02:06+00:00

Introduction:

Basic Life Support (BLS) is a fundamental component of emergency medical care for maintaining airway patency, supporting ventilation, and preserving circulation during respiratory or cardiac arrest. Poor survival rates are strongly associated with delays in recognition of symptoms, low-quality CPR and defibrillation, showing the urgency of early intervention at the community and healthcare-provider levels. The present study aimed to evaluate students' knowledge, attitudes, and practices related to Basic Life Support, to identify gaps to strengthen BLS education and training.

Methods:

This cross-sectional descriptive study was conducted from January 2025 to May 2025. A structured questionnaire was distributed online via Google Forms, where 179 respondents participated.

Results:

Females had a higher proportion of fair knowledge than males. Ethnicity and religion showed significant associations with attitude level. Nationality and ethnicity were significantly associated with practice level, with Malaysian participants and certain ethnic groups demonstrating better practice patterns.

Conclusion:

The present study highlights important knowledge and practical application gaps in Basic Life Support (BLS), despite participants' overall positive attitude. The predominance of poor-to-fair knowledge levels and suboptimal practice patterns underscores a critical disconnect between awareness and competency.